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The aim of this work was the preparation of the inclusion complex of naproxen   with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in order to improve the   physical and chemical properties of naproxen. The molecular inclusion   complexes of naproxen with HP-β-CD were prepared by using the   co-precipitation method in the solid state with the molar ratio of 1:1. The   structure of the obtained complex was characterized by using FTIR, 1H NMR,   UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis   method indicated the degradation to aromatic ketone,   2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation   started 15 days after the exposure of naproxen to daylight while the   inclusion complex of naproxen: 2-hydroxypropyl-β-cyclodextrin was   photostable for a period of 30 days. [Projekat Ministarstva nauke Republike   Srbije, br. TR 34012

The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin