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Objective of the study was evaluation of the harmful effect induced by   aluminum silicate in bone marrow chromosomes and liver tissues. Also, how   could prevents this toxicity. 60 Adult male albino rats weighing 100-120 g   were used for our experiments. The animals were divided into six equal   groups: first normal healthy control group, second group was given 200 ml   propolis/Kg day after day by stomach gavage, third group received low dose   of aluminum silicate (5 mg/kg; intra peritoneal) twice a week, forth group   injected with high dose of aluminum silicate (20 mg/kg; intra peritoneal)   twice a week, fifth group received propolis and aluminum silicate with   similar doses as that of second &amp; third groups and sixth group received   propolis and aluminum silicate with similar doses as that of second &amp; forth   groups. At the end of 8 weeks for each rat, bone marrow was aspirated and   liver was removed for lab examinations. The results showed that rats exposed   to aluminum silicate had severe chromosomal aberrations and changes in CYP   gene expression. It caused significantly increased in the frequency of   chromosomal aberrations such as polyploidy, hypoploidy, deletions,   fragments, chromatid breaks, chromosome breaks, double minutes, ring, gap   and translocation were also observed. Gene expression of CYPs was increased   with exposure to aluminum silicate and was down regulated in treatment with   propolis while Bcl-2 and BAX were decreased in exposure to aluminum silicate   and up regulated by the treatment. Propolis has a curative effect against   aluminum silicate toxicity owing to its antioxidant property.

Evaluation of protective effects of propolis against aluminium silicate toxicity in rats