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As it is known that genetic polymorphisms of glutathione S-transferases (GST)   have been associated with a variety of human diseases including cancer, we   have analyzed the impact of GSTT1 and GSTM1 null genotypes on the risk of   development of differentiated thyroid cancer (DTC) and cytogenetic changes   in peripheral blood lymphocytes of DTC patients before and after radioiodine   therapy. The polymorphism of GSTT1 and GSTM1 genes were genotyped using   multiplex polymerase chain reaction (PCR) and cytokinesis - block   micronucleus (MN) assay to assess cytogenetic changes. GSTT1 and GSTM1 null   were predominantly found in patients, but statistical significance was   observed only for GSTT1 null. The null genotypes increased risk of   development of DTC; GSTT1 null a 4.5 times (p &lt; 0.05), GSTM1 null about 3   times but on the border of statistical significance (p = 0.057), while   combination of dual null genotypes almost 7 times (p &lt; 0.05) increased risk.   No significant effects of the null genotypes as well as their interactions   with potential modifiers of MN (diagnose, age, gender and smoking habits)   were observed on both baseline and radioiodine-induced values of MN and   cytokinesis block proliferation index (CBPI) in DTC patients. Results   suggest that both GSTT1 and GSTM1 null genotypes increased risk for DTC but   to a greater extent GSTT1 null. Null genotypes of GSTT1 and GSTM1 did not   have potential to influence baseline and radioiodine-induced values of MN   and CBPI, so that absence of T1 and M1 isoenzymes did not cause increased   mutagen sensitivity of PBLs of DTC patients.

genetika

Influence of GSTT1 and GSTM1 null genotypes on differentiated thyroid cancer risk and baseline and radioiodine induced cytogenetic damage in peripheral blood lymphocytes of patients