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Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level   and function of secreted cytokine; therefore, SNPs can influence the immune   response. The aim of the present study was to determine the association of   TNF-α -308G/A single nucleotide polymorphism in tuberculosis patients in the   Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in   the promoter region was genotyped by using the allele-specific PCR method in   200 healthy controls and 124 tuberculosis patients. The distribution of   allele frequencies for TNF-α -308G/A polymorphism between control and   tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5).   Furthermore, no statistically significant association was found between TNF-α   -308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our   results suggest that TNF-α -308G/A polymorphism has no measurable effect on   the development of tuberculosis in Azeri population of Iran

TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran