Open AccessMEF2B gene SNP markers of meat productivity in Severokavkazskaya sheep breed
Author(s) -
Vladimir Trukhachev,
Valery Belyaev,
Andrey Kvochko,
А. Н. Куличенко,
Д. А. Ковалев,
С. В. Писаренко,
А. С. Волынкина,
Marina Selionova,
Magomet Aybazov,
Svetlaikolaevna Shumaenko,
А А Омаров,
Tatyana Mamontova,
O. A. Yatsyk,
Alexander Krivoruchko,
Milan Petrović,
V. Pantelić,
Violeta Caro-Petrović
Publication year - 2016
Publication title -
genetika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.24
H-Index - 15
eISSN - 1820-6069
pISSN - 0534-0012
DOI - 10.2298/gensr1601097t
Subject(s) - biology , breed , genetics , single nucleotide polymorphism , gene , snp , allele , coding region , myostatin , genotype
One of the new promising candidate genes defining productive qualities of sheep is MEF2B. Protein from the MEF2 group encoded by it affects the production of myostatin and the expression of the genes responsible for the growth of skeletal muscle fibers. Thus, the knowledge of the MEF2B gene structure is important for genomic selection. We have studied the structure of the MEF2B gene at sheep of Severokavkazskaya breed bred in Russia. To detect alleles we use NimbleGen sequencing technology by Roche (USA). As a result, it was revealed 14 single nucleotide polymorphisms (SNP) at the given breed. The discovered SNPare located in not coding areas. From them 7 polymorphisms are in the area of 5’ upstream gene in loci: c.-1713, c.-1319, c.-839, c.-321, c.-246, c.-161, c.-3; 6 polymorphisms are in introns, loci: c.55-51, c.258+312, c.258+380, c.259-52, c.452+95, c.452+103, 1 SNP is in 3’ downstream gene, c
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