English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was aimed to investigate the effects of Wenyangbushen formula on   the mRNA and protein expression of VEGF, OPG, RANK, and RANKL in the steroid-   induced avascular necrosis of the rabbit femoral head (SANFH) and to further   explore the potential mechanism of this formula on the treatment of SANFH.   One hundred and thirty six New Zealand rabbits were randomly divided into 5   groups (n=24 rabbits in each group): normal group, model group, Traditional   Chinese Medicine (TCM) Wenyangbushen decoction at low, moderate and high dose   group. The normal group and positive control group were intragastrically   (i.g.) administered with saline. The TCM group was treated with Wenyangbushen   decoction at the indicated dosage. After treated for eight weeks, the mRNA   and protein expression of VEGF, OPG, RANK, and RANKL in the femoral head   tissues was determined by RT-PCR and Western blotting, respectively.   Wenyangbushen decoction treatment can effectively promote bone cells,   osteoblasts and chondrocytes growth, as well as prevent the cell apoptosis in   SANFH. The mRNA and protein expression of OPG and VEGF was increased while   the levels of RANK and RANKL were reduced in the necrotic tissue of model   group compared with those in the normal rabbits. And Wenyangbushen treatment   prevented those changes, as manifested by up-regulation of VEGF and OPG,   while down-regulation of RANK and RANKL levels in a dose-dependent manner.   Wenyangbushen Formula treatment can alleviate necrosis of femoral head   induced by steroid. It can promote bone cells, osteoblasts and chondrocytes   growth, as well as prevent the cell apoptosis. Meanwhile, it up-regulates OPG   and VEGF while inhibits RANK and RANKL expression. This may be one of the   mechanisms for the effective treatment of SANFH

Wenyangbushen-induced-expression of VEGF, OPG, RANK, and RANKL in rabbits with steroid-induced femoral head avascular necrosis