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Model of hydrogen bonding networks in active site of -lactamase during the last intermediate EY of acylenzyme reaction semicycle is presented. The I-V characteristics of each hydrogen bond are calculated following Marcus theory and theory of protein electrostatics. Simulations showed that HBN characteristics are similar to the characteristics of microelectronic devices such as amplifier, signal modulator, triangular pulse source. The results demonstrated the analogy of HBNs in the active site of β-lactamase protein to microelectronic integrated circuit with multiple outputs each with different characteristics. Bioelectronics is a relatively new field associated with the integration of biomolecules with electronic elements to yield functional devices. The first molecular materials used in electronics originate from material science and are related to the development of electronic and optoelectronic devices that utilize the macroscopic features of organic compounds. The remarkable biochemical and biotechnological progress in tailoring new biomaterials by genetic engineering or bioengineering provides unique and novel means to synthesize new enzymes and protein receptors, and to engineer monoclonal antibodies for nonbiological substrates (such as explosives or pesticides) and DNA-based enzymes. All these materials provide a broad platform of functional units for their integration with electronic elements. After many years of research, the organic light-emitting devices, synthetic electronic circuits, chemical and biochemical sensors have drawn attention. Molecular scale devices attract substantial research efforts because of the basic fundamental scientific questions and the potential practical applications of the systems. In

Demonstration of protein hydrogen bonding network application to microelectronics