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This study investigates using of high molecular weight hydrophilic polymers,   hypromellose and hydroxypropylcellulose, for the preparation of sustained   release matrix tablets containing high dose, highly soluble drug, tramadol   HCl. Proportion of polymer, type of insoluble filler, proportion of tramadol   HCl, amount of drug in the tablet and compression pressure were recognized as   critical formulation and process parameters and their influence on drug   release and tablet mechanical properties was evaluated. Tensile strength was   used as indicator of mechanical properties of the tablets. Experiments were   performed with utilization of compaction simulator as a device which   simulates compaction profiles of large scale rotary tablet presses. In   formulations with both polymers proportion of tramadol HCl was the most   critical formulation parameter wherein increasing of the tramadol HCl   proportion increased its release rate in early stages of drug release.   Regarding the tablet mechanical characteristics, the influence of the filler   type has the most pronounced effect in formulations with both polymers.   Higher tensile strengths were obtained with Avicel PH 102 as filler in   formulations with both HPMC and HPC. [Projekat Ministarstva nauke Republike   Srbije, br. TR 34007