English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Transmucosal nasal delivery has been recognized as up-and-coming option for   delivery of therapeutic compounds. However, the short residence time of the   formulation within the nasal cavity coupled to its low permeability is   regarded as the barrier to good bioavailability. To overcome those   limitations, we developed a new formulation - nanosized Fluticasone   Propionate (FP) nasal spray. High pressure homogenization (HPH) was employed   to achieve effective particle size reduction. Latin square experimental   design (LSED) was implemented for high pressure homogenization process. With   optimized process conditions, the resulting particles were less than 250 nm   in size. The aging effect in FP nanosuspensions after 30-day refrigerated   storage was not considerable. However, for long-term storage, a combination   of homogenization and lyophilization (HL) was required to acquire stable FP   nanocystals. The crystallinity of FP was examined by differential scanning   calorimetry (DSC) and powder X-ray diffraction (PXRD), and no alternation   was observed before or after homogenization and lyophilization process. The   finished nasal spray offered a more uniform drug content compared to   marketed formulation, which ensure the consistency and reproducibility of   dose delivery. The study confirmed the effectiveness of homogenization, the   usefulness of Latin square design and the feasibility of nano nasal spray

Preparation of nanosized Fluticasone Propionate nasal spray with improved stability and uniformity