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A simple, specific, accurate and precise reverse phase high pressure liquid   chromatographic method has been developed for the simultaneous determination   of Paracetamol and Lornoxicam from tablets and to characterize degradation   products of Lornoxicam by reverse phase C18 column (Inertsil ODS 3V C-18, 250   x 4.6 mm, 5 μ). The sample was analyzed using Buffer (0.02504 Molar):   Methanol in the ratio of 45:55, as a mobile phase at a flow rate of 1.5   mL/min and detection at 290 nm. The retention time for Paracetamol and   Lornoxicam was found to be 2.45 and 9.40 min respectively. The method can be   used for estimation of combination of these drugs in tablets. The method was   validated as per ICH guidelines. The linearity of developed method was   achieved in the range of 249.09 - 747.29 μg/mL (r2=0.9999) for Paracetamol   and 4.0125 - 12.0375 μg/mL (r2=0.9999) for Lornoxicam. Recoveries from   tablets were between 98 and 102%. The method was validated with respect to   linearity, accuracy, precision, robustness and forced degradation studies   which further proved the stability-indicating power. During the forced   degradation studies lornoxicam was observed to be labile to alkaline   hydrolytic stress and oxidative stress (in the solution form). However, it   was stable to the acid hydrolytic, photolytic and thermal stress (in both   solid and solution form). The degraded products formed were investigated by   electrospray ionization (ESI) time-of-flight mass spectrometry, NMR and IR   spectroscopy. A possible degradation pathway was outlined based on the   results. The method was found to be sensitive with a detection limit of 0.193   μg/ml, 2.768 μg/ml and a quantitation limit of 0.638 μg/ml, 9.137 μg/ml for   lornoxicam and paracetamol, respectively. Due to these attributes, the   proposed method could be used for routine quality control analysis of these   drugs in combined dosage forms

RP-HPLC assay method development for Paracetamol and Lornoxicam in combination and characterization of oxidative degradation products of Lornoxicam