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A new simple, accurate, precise, highly sensitive and reproducible difference  spectrophotometric method for the determination of leflunomide in bulk and  pharmaceutical dosage form is described. Difference spectroscopic method is  based on the principle that leflunomide exhibit two different forms; in  acidic and basic medium which differs in their absorption spectra. The  difference spectra were obtained by reading the absorbance of leflunomide in  0.1N HCl in the reference cell and the absorbance of leflunomide in 0.1N NaOH  in the sample cell and vice versa; in the difference spectrum maxima and  minima were seen at 293.5nm and at 261.5nm respectively. The amplitude values  were calculated, which was plotted against concentration. The method is found  to be linear in the concentration range of 2-12 μg/ml. The percentage  recovery was found to be between the ranges from 98.92 % to 99.08 %. The  proposed method was statistically validated and successfully applied for  analysis of tablet dosage forms

Development of difference spectrophotometric method for the estimation of leflunomide in tablet dosage form