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This paper presents the harmful rodents in alfalfa in Serbia in the first  decade of this century. We also review the products registered and assessed  the efficiency of conventional (acute) rodenticides, anticoagulant and  rodenticides based on environmentally friendly active ingredients. In  addition to anticoagulants of second generation, whose mechanism of action is  based on a synthesis of the factors preventing blood coagulation, in the  latest of the eighties, and in early of nineties introduced products based on  vitamin D3-cholecalciferol. Their mechanism of action is based on the  mobilization of calcium from bone and tissue and calcification of blood  vessels, kidney, liver, heart muscle leading to delays in the work of these  bodies. The last decade of the last century have been recorded and products  based on trace element selenium (Se), the mechanism of action is based on the  replacement of thiol functional enzymes SS groups. Also presents the  possibility of application of ecological cellulose product in the field. In  the world, so far, cellulose based rodenticides are only registered in  municipal buildings. Its mechanism of action is based on interference with  the absorption of water leading to dehydration in rodents. Rodents do not  develop resistance to products based on vitamin D3 and selenium, a cellulose  product is favourable toxicological and eco-toxicological point. [Projekat  Ministarstva nauke Republike Srbije, br. III 46008: Development of integrated  management system harmful organisms in crop production in order to overcome  resistance and improve the quality and safety of food]

The justification for application and development trends of non-conventional rodenticides in protection of alfalfa from rodents