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The aim of this study was to evaluate the serum proteins electrophoretic   pattern and the concentrations of acute phase proteins in calves with chronic   bronchopneumonia. Twenty-eight calves with clinical symptoms of disease were   included into the evaluation. Blood serum was analyzed for total protein   concentrations (TP), total and relative values of serum protein fractions,   albumin/globulin ratio (A/G) and the concentrations of selected acute phase   proteins - haptoglobin (Hp), serum amyloid A (SAA), and fibrinogen (Fbg). The   results recorded in sick animals were compared with those in 36 clinically   healthy calves as control group. In calves suffering from chronic   bronchopneumonia we found significantly higher total serum protein   concentrations than in healthy calves (p<0.001). In sick calves a marked   shift in the concentrations of most of the protein fractions was observed,   with significantly higher mean total values of α1- (p<0.001), β1- (p<0.01),   β2- (p<0.001), and γ-globulins (p<0.001) and relative mean values of α1-   (p<0.01), β2- (p<0.01), and γ-globulins (p<0.001). On the other hand, the   concentrations of albumin and A/G ratios were in calves with respiratory   diseases significantly lower than those measured in healthy ones (p<0.001).   The mean concentrations of α2- globulins did not differ significantly between   the two groups of animals. In the affected calves significantly higher mean   values of Hp, SAA, as well as Fbg (p<0.001) were described. The presented   results suggest a marked effect of chronic bronchopneumonia in calves on most   of the evaluated protein profiles and acute phase protein variables with a   marked shift in the albumin and globulin concentrations

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases