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The aim of this study was to examine the regional distribution of opiate  alkaloids from seized heroin in experimental animals' brain regions and  blood. Results could be used in the examination of opiate alkaloids'  distribution in human biological samples in order to contribute to the  solution of the causes of death due to heroin intake. Experimental animals  (Wistar rats) were treated with seized heroin, and were sacrificed at  different time periods: 5, 15, 45 and 120 min after treatment. Opiate  alkaloids' (codeine, morphine, acetylcodeine, 6- acetylmorphine and  3,6-diacetylmorphine) content was determined in the brain regions (cortex,  brainstem, amygdala and basal ganglia) and blood of animals using gas  chromatography-mass spectrometry (GC-MS) method. The highest content of  opiate alkaloids in the blood was measured 15 min, and in the brain tissue 45  min after the treatment with heroin. The maximal concentration of opiates was  determined in the basal ganglia. The obtained results offer the possibility  of selecting this part of the brain tissue as a representative sample for  identifying and assessing the content of opiates

Regional distribution of opiate alkaloids in experimental animals' brain tissue and blood