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The aim of this study was to compare the protective effect of two individual  oximes (HI-6 and trimedoxime) with their combination in mice acutely  poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect  experimental animals against either dichlorvos, heptenophos or tabun.  Trimedoxime was very effective against all three OPs. The ED-500 doses of  trimedoxime necessary to protect 50% of animals after the simultaneous  administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in  dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of  efficacy in the tabun protocol was approximately three and two times longer  than in the protocol for heptenophos and dichlorvos, respectively indicating  also that trimedoxime is very potent in counteracting tabun toxicity.  Addition of trimedoxime significantly improved the protective effect of HI-6  in acute tabun poisoning. When dichlorvos or heptenophos were used, addition  of trimedoxime generally improved the antidotal effect of HI-6, but still  lower protection was obtained than in the case when trimedoxime alone was  administered. The investigations of different oxime combinations have  indicated that application of a mixture of two oximes represents a promising  antidotal approach

Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos