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Many studies in hypertensive humans and animals have shown that increased  blood viscosity is in direct relation with essential hypertension. The aim of  our studies was to investigate the effects of chronic hematocrit value  changes on arterial blood pressure and kidney function in genetically induced  hypertension. To this end, we studied the effects of several interventions,  designed to increase/decrease hematocrit, on hemodynamic parameters, vascular  reactivity, glomerular filtration and renal function curve in spontaneously  hypertensive rats (SHR). Results of our study show that chronic hematocrit  value elevation increases blood pressure and peripheral vascular resistance  in SHR. On the other hand, chronic hematocrit lowering elucidates blood  pressure and peripheral vascular resistance decrease followed by cardiac  output rising. Both hematocrit value changes significantly reduce  vasodilatory vascular response. Hematocrit lowering induces acute renal  failure. Sodium excretion is shifted to higher blood pressure values in high  hematocrit value animals and opposite - lower blood pressure values in low  hematocrit value animals. Repeated transfusions develop salt sensitive  malignant hypertension in SHR. Further studies are necessary to evaluate the  degree of kidney damage after chronic hematocrit value changes in SHR

Chronic changes of hematocrit value alter blood pressure and glomerular filtration in spontaneously hypertensive rats