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The purpose of this study was to investigate the biocompatibility of different dental materials for teeth root canal obturation, implanted in rat muscular tissue, by analyzing the type of muscular tissue inflammatory reaction level. In the preparation of Wistar rats M. biceps femoris, three different materials for root canal obturation were implanted: Sealapex (Kerr, Romulus, USA), AH-26 (DE Trey, Zurich, Switzerland) and Spongio cement material based on polymethil metacrylate - PMMA (Tomić, 1981, US patent 4296209). The used control material was sterile wax. The rats were sacrificed 30 and 60 days after implantation and the response of the tissue on implanted material was evaluated with standard histological methods on 6 _m sections stained with hematoxilin and eosin. Implantation of Sealapex in rat muscle tissue produced a strong acute inflammation, infiltration with massive polymorphonuclear and numerous giant cells. Acute inflammation still persisted 60 days after implantation. AH-26 produced a strong reaction around the alien body with predominantly limphocitic infiltration. Giant cells and macrophages contained phagocited pieces of material. After 60 days expressive chronic myositis was present with a mass of giant cells and proliferation of connective tissue. Thirty days later the results of histological investigations suggested that implanted PMMA based material still produced a connective fibrous capsula made of fibroblasts and fibrocytes around the implanted material. In the muscular tissue myositis developed forming granulomatous tissue. After 60 days a capsula was made of mature hyalinisated connective tissue without signs of inflammation in the surrounding muscular tissue. The reaction is similar to the reaction to inert control material, such as sterile wax. These findings suggest biocompatibility of PMMA based material for canal obturation

Biocompatibility of root canal obturation materials implanted in rats muscular tissue