English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Cytokeratins belong to the most fundamental markers of epithelial  differentiation. Their composition reflects both a cell type and the  differentiation status. The aim of this study was to investigate the  expression of keratins 8 and 17 in normal cervical epithelium, mature and  immature metaplastic epithelium as well as in various grades of  intraepithelial neoplasia and squamous cell carcinomas. Fifty-eight smears  representing 20 normal, 23 LGSILs, 12 HGSILs and 3 cervical carcinomas were  stained with anticytokeratin 8 (clone 35bH11) and anticytokeratin 17 (clone  Ks17E3). Expression of both keratins was examined and the percentages of  immunoreactive normal, metaplastic, intraepithelial neoplastic and malignant  cells were determined. Evaluation of tissue sections was also performed.  Keratin 17 was identified in all SILs and carcinomas. It was also present in  3/20 (15%) of normal cervical smears that contained immature metaplastic  cells. Keratin 8 was found in the majority of LGSIL cases 20/23 (86.9%), in  all HGSIL and malignant lesions as well as in endocervical columnar  epithelial cells and in 5/20 (25%) normal smears with immature metaplastic  cells. Both keratins showed a more extensive and intense expression in severe  lesions. Evaluation of tissue sections revealed expression of CK8 and CK17 of  various intensity in most of the premalignant and malignant cases.  Premalignant and malignant cells showed similarities in cytokeratins 8 and 17  expression. Both CKs were not expressed in normal ectocervical epithelium.  The study of the expression of CK8 and CK17 may contribute in detection of  cervical intraepithelial neoplasia

Expression of cytokeratins 8 and 17 as a diagnostic marker of cervical intraepithelial neoplasia