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Leptospirosis caused by pathogenic Leptospira species is a worldwide zoonotic   2 infectious disease, but the mechanisms of leptospiral internalization   remain poorly understood. Here, we report that mouse J774A.1 macrophages   expressed integrin-subfamily proteins (ITGB1, ITGB2 and ITGB3). Antibody   blockage and siRNA-based knockdown of ITGB1 decreased the internalization of   leptospires into mouse J774A.1 macrophage cells. The internalization required   focal adhesion kinase (FAK) activation in J774A.1 cells rather than   phosphoinositide-3-kinase (PI3K), and microfilament rather than microtubule   aggregation during infection. The data indicated that the   ITGB1/FAK/microfilament signaling pathway is responsible for leptospiral   internalization in mouse macrophages

Signaling via ITGB1/FAK and microfilament rearrangement mediates the internalization of Leptospira interrogans in mouse J774A.1 macrophages