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Endophytes of plants have a wide range of strains comprising important   sources of various bioactive metabolites. An endophytic fungus was isolated   from honeysuckle, an important Chinese medicinal plant. The phylogenetic and   physiological characterization indicated that the isolated strain   JY2corresponded to Fusarium sp. The culture filtrate of JY2displayed   antagonism activity against some pathogenic bacteria owing to the existence   of antimicrobial compounds. The filtrate revealed the strongest in vitro   antimicrobial activity on Pseudomonas aeruginosa by increasing the   permeability of cell membranes. The antibacterial extract was fractionated   and purifiedusing silica gel chromatography. Five different bioactive   compounds were isolated by bioactivity-guided fractionation from the culture   extracts of JY2, and preliminarily identified by HPLC-MS spectral data. These   results suggest that Fusarium sp. features a potentially remarkable   antimicrobial activity and could be valuable to discover the new drugs or   agents for antimicrobial purposes

Antimicrobial activity of endophytic fungus Fusarium sp. isolated from medicinal honeysuckle plant