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The Brazilian Savanna (locally called “Cerrado”) is an important biome  presenting several plants that are used in popular medicine. However, the  risks associated with the consumption of derivatives from these plants are  generally unknown. Studies with compounds obtained from different species  have shown the risks of DNA damage. The present work assessed the in vivo  mutagenicity of three plant species used in popular medicine to treat human  gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea  multiflora). The micronucleus assay was performed in peripheral blood of mice  submitted to acute treatments. Results showed that no assessed extracts were  mutagenic in vivo. In fact, the absence of mutagenicity in the present study  indicates that the extracts do not contain compounds capable of inducing DNA  breaks or chromosomal loss. However, further analysis should be performed in  others systems to guarantee their safety, mainly to human chronic use

Absence of mutagenicity of plants used to treat gastrointestinal disorders