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The present study was conducted to evaluate the effects of zinc cyanide  (Zn(CN)2) on the ATPase (Na+-K+-, Mg2+, Ca2+) activity of the freshwater fish  Cirrhinus mrigala (Ham). Fish were exposed to two sublethal concentrations  (0.114 and 0.068 mg/L) and the effects were studied in the liver, muscle and  gill tissues at the end of 5, 10 and 15 days of exposure. Cyanide  intoxication resulted in marked changes in ATPases, represented by a  significant decrease in the activities. Maximum inhibition was observed at  higher concentration. The order of inhibition in the activity was Na+-K+->  Ca2+ > Mg2+ ATPase. These results imply an immediate adaptive response to the  stress, demonstrating alterations in ATPase activities in the tissues of  cyanide-treated fish. The present study clearly proposes that ATPases can be  used as biomarkers of exposure of aquatic organisms to cyanide intoxication

Effect of exposure to sublethal concentrations of zinc cyanide on tissue ATPase activity in the fresh water fish, Cirrhinus mrigala (Ham)