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This case control study investigated the serum and synovial fluid adiponectin levels in 33 patients with rheumatoid arthritis (RA) and 26 patients with osteoarthritis (OA) as the control group.A venous blood sample was collected from each patient in fasting condition to measure plasma adiponectin. At the same time, synovial fluid was aspirated aseptically from the swollen knee joint of all patients and controls. Blood and synovial fluid samples were centrifuged at 5,000 rpm for 5 min, then frozen and stored at -20 °C. For analysis of data, the independent t test, Mann-Whitney test, Kolmogorov-Smirnov test, Pearson’s correlation, and linear regression analysis were utilized.Serum and synovial fluid adiponectin levels were significantly higher in RA patients than OA subjects (P valueThe present study revealed that adiponectin levels were increased in the serum and synovial fluid of RA patients compared with OA patients, and these levels may have a significant role in the pathogenesis of RA.

The importance of synovial adiponectin values in patients with rheumatoid arthritis in comparison with osteoarthritis