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espanolA rifampicina (RFP) pode ser administrada diariamente ou num esquema intermitente. Quando e administrada de forma intermitente pode produzir reacoes imuno-alergicas graves. Apresentamos o caso clinico de um paciente que, apos tratamento com RFP de forma intermitente para uma infecao por Mycobacterium intracellulare, desenvolveu quadro de necrose tubular aguda, anemia, prolongamento dos tempos de coagulacao e citolise hepatica ligeira. Apos suspensao do farmaco houve recuperacao em 24h das alteracoes da coagulacao e da citolise hepatica, tendo tido no entanto necessidade de hemodialise por persistencia de anuria e uremia, e transfusao de concentrados de eritrocitos pela gravidade da anemia. Teve alta com recuperacao de todas as disfuncoes EnglishRifampicin (RFP) may be administered on a daily or intermittent base. When administered intermittently it can produce severe immunoallergic reactions. We present a report of a patient who developed acute tubular necrosis, anemia, prolongation of clotting times and mild hepatic cytolysis after therapy with RFP on an intermittent basis directed to a Mycobacterium intracellulare infection. After suspension of the drug the patient recovered from clotting disturbance and hepatic cylolysis in 24h, but required hemodialysis for persistent anuria and uremia, and packed cells transfusion because of the severity of anemia. He was discharged with total recovery of all those dysfunctions.

Necrose tubular aguda e anemia grave após uso intermitente de rifampicina