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S-nitrosoglutathione (GSNO), a nitric oxide donor (NO), has been used as a vasodilator, antiplatelet and displays therapeutic potential for the treatment of cardiovascular diseases. In this study, GSNO was incorporated into polymeric films made of poly(3-hydroxybutyrate) (PHB) and of poly(3-hydroxybutyrate)/propylene glycol (90/10) (PHBPPG 90/10), being evaluated the thermal stability of the films by differential thermal analysis and thermal analysis. The results indicate there is interaction between the different matrices and the drug, especially a higher increase in the degradation temperature and fusion for films constituted of PHB and GSNO. Key-words: Differential thermal analysis, poly (3-hydroxybutyrate), Snitrosoglutathione, thermal analysis.

ESTUDO DA ESTABILIDADE TÉRMICA DE FILMES POLIMÉRICOS CONSTITUÍDOS DE POLI (3-HIDROXIBUTIRATO) E PROPILENOGLICOL CONTENDO O FÁRMACO S-NITROSOGLUTATIONA