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145 Cell and Organ Transplantology. 2018 November; Vol. 6, No. 2 Among the demyelinating diseases of the central nervous system (CNS), particular attention is paid to multiple sclerosis, which affects mainly young people and occupies the 2nd place among diseases of the nervous system causing disabilities in Ukraine [1]. Existing approaches to the pharmacotherapy of this pathology are not always effective, and the long-term use of drugs is accompanied by significant side effects. A promising trend in the treatment of multiple sclerosis may be the use of transplanted stem cells of various sources, as well as approaches Neuroprotective effect of melatonin in mice with toxic cuprizone model of demyelination and possible pathways of its realization Cell and Organ Transplantology. 2018; 6(2):145-151. doi:10.22494/cot.v6i2.87