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Malignant gliomas of the brain are characterized by invasive growth and resistance to the treatment and have a poor prognosis for patients’ lives. Highly malignant gliomas can not be treated by surgical resection; and toxicity of chemotherapy and radiotherapy limits the doses that can be used. The use of neurogenic stem cells (NSCs) and neurogenic progenitor cells (NPCs) is one of the areas of cell therapy of brain and spinal cord lesions. Intensive research of NSCs biology has revealed its tumor tropic properties. A great potential of migration and incorporation of NSCs in the place of the pathology in the CNS can consider their use as a means of targeted therapy of tumors [1-7]. Antitumor properties of NSCs substantiate the development of strategies of malignant gliomas treatment with NSCs [8-10]. The issue of possible mechanisms for implementing of NSCs/NPCs anti-tumor properties is understudied; and, since there are prospects of their use for the treatment of brain lesions and malignant brain tumors, a research in this area is important. The aim of the paper was to study the effect of rat neurogenic cells supernatant (NCS) on the tumor-inducing ability of 101.8-glioma cells at the intracerebral implantation in rats. The studies were conducted on white rats (n = 60 males, weight 120±10 g) from the vivarium of A. P. Romodanov State Institute of Neurosurgery NAMS of Ukraine. All animal experiments were performed in accordance with Law of Ukraine “On protection of animals from cruelty”, the “European Convention for the Protection of Vertebrate Animals used for experimental and other scientific purposes”, all norms of bioethics and biosafety and were approved by Bioethics Committee. The animals were kept under standard vivarium conditions; anesthesia and euthanasia were performed under ether anesthesia. The model of glioma 101.8 was prepared by intracerebral administration 0.02 ml (3,5·105 viable cells) of native or modified strain of 101.8-glioma cells suspension (All-Russian Collection of Cell Cultures, Institute of Human Morphology of Russian Academy of Sciences, Moscow, Russia) in the left hemisphere of the rat brain to the depth of 1.5-2.0 mm. Strain 101.8 is an anaplastic glioma in which astrocytes glia oligodendroglia and ependyma underwent simultaneous malignancy, and its histobiological properties are close to the human malignant gliomas [11]. ABSTRACT

Effects of the neurogenic cells supernatant on the tumor-inducing ability of glioma 101.8 in rats