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Aims: This work presents a method &amp; instrumentation to measure pressure-dependent intra-cardiac cycle variations in local blood pulse velocity PWV (P)  using Bramwell-Hill (BH) equation by incorporating Kelvin-Voigt type viscoelastic modelling.Methods: A pilot in-vivo study on 8 subjects was conducted to verify the technique&#x2019;s functionality. The carotid diameter D and pressure P waveforms (sampled at 1 kHz) were measured using our extensively validated image-free ultrasound technology ARTSENS and a calibrated tonometer respectively.Results: Measurement system captured high fidelity P and D signals. Employing the viscoelastic modelling, elastic P-D curves were obtained and PWV (P)  was calculated. The reliability of these curves was verified by comparing the stiffness index derived from the fit (&#x03B2; fit ) against the theoretically calculated value &#x03B2; ref  which strongly correlated (r = 0.98, p &#x003C; 0.05). The systolic PWV (PWV s ) was approximately 20% higher than diastolic PWV (PWV d ). The group average PWV s  and PWV d  were higher for hypertensive subjects.Conclusion: The proposed technique reliably measures the intra-cardiac cycle variations in PWV (P)  and addresses various key considerations associated with non-invasive implementation BH equation for the same.

Incorporating Arterial Viscoelastic Modelling for the Assessment of Changes in Pulse Wave Velocity Within a Cardiac Cycle Using Bramwell-Hill Equation