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The mechanism underlying Wolff-Parkinson-White syn-drome features accessory conduction between the atrium and ventricle. However, the morphological and electro-physiological details remain unclear. Here, we performed preliminary computer simulations of anterograde, accessory pathway conduction using a simplified wall model. Our model features simplified atrial and ventricular walls, and a myocardial bundle (the accessory pathway). The action potentials of these components were represented by Courtemenche and O&#x2019;Hara-Rudy models. We performed computer simulations to explore relationships among accessory pathway bundle size, intercellular conductivity, and anterograde conduction. We found that a thick accessory pathway facilitates anterograde conduction, ventricular conductivity promotes such conduction, and the accessory pathway prevents anterograde conduction. Source-sink mismatch may explain the first two points; an electro-tonic effect may explain the last one. Our findings provide new insights into the morphological and electrophysiological details of the accessory pathway.

Computer Simulation of Anterograde Accessory Pathway Conduction in Wolff-Parkinson-White Syndrome with a Simplified Model