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Our aim was to assess the effects of 21-days head-down (−6 degrees) bed-rest (BR) and effectiveness of sledge jump countermeasure (CM), on aortic flow and morphology by Phase Contrast (PC) MRI. Male subjects were enrolled at :envihub (DLR, Germany) in control (CTRL, N=12) or countermeasure (CM, N=12) groups. PC-MRI images were obtained before and after 21-days of BR, and analyzed with custom software. Semi-automated region growing and thresholding were applied to segment the aortic lumen, and to compute parameters from velocity images: area lumen (AL), flow velocity, stroke volume (SV), flow rate (Qpeak), time-to-peak flow, systolic duration and heart beat duration (RR). After 21 days, in CTRL significant decreases in SV (14%), Qpeak (5%) and AL (4%) were observed compared to baseline values. Conversely, for CM no changes were observed in these parameters, but only in RR (−8%). Cardiac adaptation to deconditioning due to immobilization resulted in a reduction of SV and Qpeak that might have induced a remodeling process in the ascending aorta, by shrinking of its lumen. The applied CM seemed to counteract at least partially these effects.

Aortic Flow and Morphology Adaptation to Deconditioning after 21:Days of Head:Down Bed:Rest Assessed by Phase Contrast MRI