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Human and animals can accidentally be exposed to heavy metals from the environment, such as lead (Pb). Lead toxicity caused oxidative stress. It can increase production of free radicals, and induces several responses to physiological and biochemical changes in the body. Curcumin was the active ingredient of  ginger, has the potential an antioxidant as a natural herbal medicinal. The objective of this research was to evaluate the antioxidant activity of curcumin in mice that were given lead exposed. Research was conducted by twenty five male mices, were grouped into five treatments: P1 (control), P2 (Pb 75 mg/Kg BW), P3 (Pb 150 mg/Kg BW), P4 (Pb 75 mg/Kg BW + curcumin 20 ppm), P5 (Pb 150 mg/Kg BW + curcumin 20 ppm). In this research, carried out by in vitro and in vivo testing. The results showed that in vitro antioxidant activity of curcumin by DPPH method was very strong, an IC-50 was 10.5 ppm. Lead concentration in the liver also increases in the lead treatment. Lead exposure increasing malondialdehyde (MDA) blood serum levels and administration of curcumin reducing MDA serum levels significantly. In conclusion, oxidative stress caused by lead can be treated with curcumin.

ANTIOXIDANT ACTIVITIES OF CURCUMIN TO MDA BLOOD SERUM CONCENTRATION AND LEAD LEVELS IN LIVER OF MICE