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BACKGROUND/OBJECTIVES: Total serum lactate dehydrogenase (LDH) and LDH isoenzymes are found increased in tissue damaging diseases. Literature reveals that LDH and its isoenzymes specifically LDH-3 increase in blood due to damage of lung tissue. Acute bronchitis is diagnosed only on clinical grounds and no laboratory tests had been established to confirm diagnosis. This study was conducted to establish a guiding factor that can be helpful in assessment of lung tissue damage and this finding will be having prognostic importance including drug effectiveness in acute bronchitis patients which can be helpful in prevention of developing the chronic course of illness. METHODS: Patients were collected from Out Patients Department of Liaquat University Hospital Jamshoro / Hyderabad, Sindh - Pakistan. Total serum LDH was estimated by spectrophotometer and LDH isoenzymes were measured by electrophoresis on cellulose acetate membrane. RESULTS: Total serum LDH (260.84±7.08mu/ml p<0.001) and LDH-3 (65.60±1.92mu/ml p<0.001) were found statistically significant as compared to control subjects. CONCLUSION: Increased serum LDH and LDH-3 are marker for extent of lung tissue damage. Monitoring of these parameters can be a better guide for the prognosis and treatment including drug effectiveness in patients of acute bronchitis.

SERUM LACTATE DEHYDROGENASE ISOENZYMES AS MARKER FOR LUNG TISSUE DAMAGE IN ACUTE BRONCHITIS PATIENTS