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Endophytic microbes have been reported to havean important in the production of secondary metabolites by the host plants. Moreover, some researches reported that these microbes, specifically endophytic fungi, are also able to produce metabolites to cure diseases, such as metabolic syndrme diseases. This study was conducted as a preliminary research to explore the potency of endophytic fungi isolated from fruits of Averrhoa bilimbi Linn. As an alternative resource for antidiabetes compounds production. Here, we screened the antidiabetes activity by analyzing the alfa amylase inhibition activity. Several steps were performed in this research, which started by isolating endophytic fungi from sterilized fresh fruits, fermentation and extraction, and anti-diabetes activity analysis through alpha-amylase inhibition assay as the final step. In this study, we obtained 12 endophytic fungi isolates with different morphological characteristics between isolates have the potential to produce antidiabetic compounds that are seen from the ability to inhibit the activity of the alpha amylase enzyme. The most potential isolate was BW-10 isolate which had the highest inhibitory activity among other isolates, which is 45.564%. Molecular identification results showed isolate BW-10 has a similarity sequence of 99% with Trametes elegans isolate. Antidiabetics activity through various in vitro and in vivo evaluation and secondary metabolites identification are possible to be conducted as further research.

Potensi Kapang Endofit Belimbing Wuluh sebagai Kandidat Penghasil Senyawa Antidiabetes