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Indole-3-carbinol is sold as a sole ingredient in dietary supplements or as a combination nutraceutical along with a variety of herbs and/or vitamins. It is marketed for its potential ability to prevent cancer and provide other health benefits, such as detoxifying the liver and boosting the immune system. Indole-3-carbinol is a naturally formed breakdown product of glucosinolate glucobrassicin, a component found in cruciferous vegetables of the Brassica genus, including broccoli, brussels sprouts, cauliflower, cabbage, kale, kohlrabi, and turnips. Exposure to indole-3-carbinol occurs through the oral route through the ingestion of Brassica vegetables or dietary supplements. Indole-3-carbinol was nominated by the National Cancer Institute for toxicity and carcinogenicity testing because of its occurrence in natural products and for its potential use as a breast cancer chemopreventive agent. Male and female F344/N rats and Harlan Sprague Dawley rats received indole-3-carbinol in corn oil by gavage for 3 months or 2 years, respectively. Male and female B6C3F1/N mice received indole-3-carbinol in corn oil gavage for 3 months or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium and Escherichia coli, rat bone marrow cells, and mouse peripheral blood erythrocytes. (Abstract Abridged).

national toxicology program technical report series

NTP Technical Report on the Toxicology Studies of Indole-3-carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)