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Carbazole (1) upon condensation with ethylchloroacetate followed by treatment with hydrazine hydrate yielded 2-(9H-carbazol-9-yl) acetohydrazide (3). Treatment of compound (3) with sodium nitrite resulted in the formation of diazonium salt (4). Reaction of (4) with ethylacetoacetate and acetylacetone afforded ethyl 2-[3-(9H-carbazol-9-ylacetyl) triazanylidene]-3-oxobutanoate (5) and 3-[3-(9H-carbazol-9-ylacetyl)triazanylidene] pentane-2,4-dione (6), respectively. Reaction of (5) and (6) with phenylhydrazine and urea yielded 4-[3-(9H-carbazol-9-ylacetyl)triazanylidene]-5methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (7) and 5-[3-(9H-carbazol-9-ylacetyl) triazanylidene]-4,6-dimethylpyrimidin-2(5H)-one (8), respectively. The newly synthesized compounds were characterized by IR, 1 H-NMR and 13 C-NMR analysis. Potential antifungal effects of the synthesized compounds were investigated using the Candida albicans and Aspergillus niger strains. The newly synthesized compounds exhibited promising activities, particularly compounds (7, 8 and 9). Introduction The clinical need for therapeutic agents which restore or enhance a response in immuno compromised patients such as that which occurs in viral infections, cancer, autoimmune disease and acquired immune deficiency syndrome (AIDS) has led to the search for novel immuno stimulants (1) . Carbazole, an important class of indole alkaloids has gained much importance in recent years due to their diverse biological activities (2-5) . The therapeutic prominence of the carbazole derivatives was well established (6,7) . Also, pyrido carbazoles were reported to elicit anticancer and anti-HIV properties (8-11) and hence they have gained an important place in medicinal chemistry (12) . The discovery of the antineoplastic activity of the naturally occurring alkaloid ellipticine and its isomer olivacine Fig.(1) has stimulated considerable research efforts in the field of carbazole systems (13) . A variety of carbazoles and its annulated derivatives represent DNA ligands with pronounced antitumor activity (14) . With the aim to construct new systems with the carbazole nucleus, I turned my attention to synthesizing N-acetohydrazide carbazole that would be an important synthon for the synthesizing of new heterocycles. Ellipticine Olivacine Fig.(1) : Structures of the alkaloids, ellipticine and Olivacine. (15) Experimental Instruments: Melting points were determined on GallenKamp melting point apparatus and were uncorrected. The IR spectra of the compounds were recorded on Shimadzu FTIR-8300 spectrometer as KBr disc; results are given in cm -1 . 1 H-NMR and 13 C-NMR spectra were recorded at 300 and 75 MHz, respectively, in DMSO-d6 for all compounds on a Bruker AMX-400 NMR spectrometer. The chemical shifts are reported in part per million (ppm) downfield from internal tetramethylsilane (TMS) (chemical shift in δ values). 1 H-, 13 CNMR were made at the Organic Chemical Technology Department, Technical University of Budapest (Budapest, Hungary).

SYNTHESIS AND STUDY OF NEW N-SUBSTITUTED CARBAZOLE AS SOME ANTIFUNGAL AGENTS