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The expedition of Balmis set sail from La Coruna (Spain) in 1804 with the mission of taking the vaccine against smallpox to the inhabitants of Hispanic America. Its goal was to vaccinate as many children as possible, and, specially, to prepare the authorities of different regions to continue with this job and to bring the new cure to urban as well as to rural populations. The article will show to what extent this project was put into practice, how people reacted about it, which authorities were involved, what problems it had to face, and what the results were since 1805—year when the expedition came to San Luis Potosi— until 1821 —when the viceregal period ended.

La vacunación contra la viruela en la provincia de San Luis Potosí tras la expedición de Balmis: 1805-1821