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The present work was aimed to test the relative physicochemical and in vitro drug release properties of some popular enteric coated brands of Rabeprazole sodium tablets marketed in India. The generic drugs should accept challenges on par with patent innovative drug molecules in the in vitro evaluation parameters. Six different Indian brands of Rabeprazole sodium tablets (marketed in India) with a strength of 20 mg were purchased from the market and they were judged for uniformity of weight, thickness, diameter, hardness, disintegration time, drug content, and in vitro release. The disintegration time and in-vitro drug release studies were examined in 0.1M HCl (for 2h) and buffer solution of pH 6.8 (till drug dissolves). The evaluated brands of the Rabeprazole sodium tablets passed all the tests conducted as per the pharmacopoeial standards and comply in all the parameters. All the brands represented their resistance to disintegrate/dissolve the stomach environment (2h) and disintegrate/dissolve in the intestinal environment (within 1h). The dissolution summary revealed that the Rabeprazole sodium tablet brand (RST-1) was faster while Rabeprazole sodium tablet brand (RST-2) was slower, and the remaining brands of Rabeprazole sodium showed identical results. The authors conclude from the study that all the brands evaluated for all physicochemical constraints including in vitro dissolution are satisfactory and identical with each other, and patients can take any of these brands as prescribed by the physician.

Comparative in vitro drug release examination of dissimilar brands of Rabeprazole sodium Gastro-Resistant Tablets