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The aim of the study was to compare resistance rate against anti-retrovirals in two cohorts of children with HIV one perinatally infected from Cambodia and the other nosocomially infected in Kyrgyzstan. Patients and Methods: Two groups of HIV positive children were compared: Vertically infected Khmer children in Cambodia and nosocomially infected children in 3 hospitals in Kyrgyzstan. Results: Prevalence of S. aureus and other oral cavity comensual was much lower in Kyrgyz children in comparison to Khmer children in Original Articles 36 Clinical Social Work and Health Intervention Clinical Social Work and Health Intervention Vol. 7 No. 3 2016 Introduction Viral, parasitic, bacterial and fungal co-infections are very frequently present among HIV positive children and such conditions often require administration of antibiotics during their therapy (1-2). The spectrum of infections occurring in HIV positive children is wide and use of antibiotic prophylaxis can stimulate development of resistance (3-4). We aimed to evaluate the spectrum of infections among pediatric HIV patients receiving HAART (Highly Active Retroviral Therapy) and to assess resistance rates of those microorganisms in the two groups of children with HIV. Methods Samples obtained from 51 HIV-positive children from Osh, Bishkek, Jalal-Abad, Kara-Suu and Nookatsk, Kyrgyz Provinces who have been receiving HAART for 3 years, were included. During their previous hospital stays, children were frequently treated with ampicillin. Cultivations from samples were performed and antibiotic profiles were assessed. A group of 51 children from Kyrgyzstan was compared to 141 children from Phnom Penh and Sihanoukville. Cambodia has a 15 year follow-up program in HIV. Tab. 1 Spectrum of microorganisms colonizing the respiratory tract in Kyrgyz versus Cambodian children with HIV on HAART Species Kyrgyz children Khmer children P Neisseria catarrhalis 20.48% 51% p˂0,01 Moraxella catarrhalis AMP-R 7.23% 6.2% NS Streptococcus viridans PEN-R 20.48% 5.1% p˂0,01 Streptococcus pneumoniae PEN-R 9.64% 5.1% NS MSSA 10.84% 10.1% NS MRSA 2.41% 45.2% p˂0,001 CoNS Staphylococcus spp 8.43% 10.1% NS Candida albicans FLU-R 15.66% 10.1% NS Others* 4.82% 4.0% NS Notes: MSSA – methicillin-susceptible S. aureus MRSA – methicillin-resistant S. aureus Other: CoNS coagulase-negative staphylococci, *Escherichia coli (1), Proteus mirablis (1), Pseudomonas aeruginosa (1), Enterococcus faecalis (1) Cambodia due to type of treatment with HAART (inpatients versus outpatients). Conclusion: In inpatient setting of HIV positive children, ATB resistance is lower. 37 Original Articles Clinical Social Work and Health Intervention Vol. 7 No. 3 2016 Results and Discussion In 51 HIV positive children we found out Neisseria catarrhalis (20.48%), Streptococcus viridans (20.48%) and Candida albicans (15.66%) being the most frequent microorganisms. Interestingly, prevalence of staphylococci was not very high (1821.69%), and surprisingly, only 2 cases (2.41%) of MRSA were noticed (P˂0,01 – 0,001) Tab.1. Also, resistance rate among bacteria was really low, with clindamycin resistance acting as the most prevalent (5.6% of bacteria isolates), followed by ampicillin and erythromycin (4.9% and 2.8%, respectively). Resistance to 5-fluorocytosine was noted in one C. albicans isolate, with the rest of candida isolates being fully susceptible to all antifungals tested. Co-infection with 2 or 3 microorganisms was identified in 20 patients (39.22%).In Cambodian children, isolation of MRSA was significantly higher (P˂0.01 – 0,001) (Tab. 1) (6-7).

clinical social work journal

Antibiotic susceptibility of respiratory isolates among HIV-positive children in Kyrgyzstan is higher compared to those Cambodia: Is outpatients status important