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Six lactating ewes were orally drenched each day with polyethylene glycol (PEG) to remove the effects of the condensed tannins in sulla (Hedysarum coronarium) and six other ewes (control) received a drench of water commencing 28 days prior to the measurement period according to a block design. At week 6 of lactation, portal absorption and hepatic uptake of indole and skatole were increased by PEG. Effi ciency of hepatic extraction of indole and skatole was not different between the treatments. The splanchnic release of indole and skatole was higher in the PEG ewes compared with control.

Polyethylene glycol increases intestinal absorption and hepatic uptake of indole and skatole in sheep fed sulla