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The aim of the study was to determine the effect of megadoses of L-ascorbic acid, as a dietary supplement for rats, on the morphological status of the liver. Forty małe rats were divided into 4 groups and fed mixtures that were supplemented with ascorbic acid in the following ąuantities in the particular groups (in % of the mixtures): 1,0.0; I I , 0.3; I I I , 0.6; and IV, 0.9. The results showed that L-ascorbic acid supplemented to the mixtures at a level of 0.9% caused necrotic damage of hepatocytes.

Effect of the addition of L-ascorbic acid in megadoses to the diet on the morphology of liver cells in rats