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The relationship between the ligand-binding activity of growth hormone receptor (GH-R) and polymorphism \nAlul, Accl and Stul sites in the 5' flanking region of bovine GH-R gene was examined. The study was performed on twenty six 15-month old bulls of dairy (Friesians) and beef breeds (Charolais, Limousine, Piemontese, Aberdeen Angus, Hereford). Receptor binding capacity (B m a x ) and dissociation constant (K d ) for GH-R were determined by the Scatchard method. The polymorphism in the GH-R gene was analyzed by PCR-RFLP technique. Our results showed significant differences in the liver GH-R B and K. between the dairy and beef breeds. B was greater (P<0.05)

Ligand-binding activity of growth hormone receptor (GH-R) in bulls of different breeds with identified GH-R genotypes