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The dispersion of individual pixels parameters is w dely studied in the field of hybrid pixel detector s for X-ray detection. CERN is developing methods of thresholds equalization to correct for threshold dispersion between pixels of the Medipix3RX readout chip. In this paper, we focus on the complex probl em of pixel-to-pixel dead time dispersion, due to the dispersion of the shape of analog pulses and to the residual threshold dispersion after equalization. In tomogra phy, dead time inhomogeneity is responsible for rin g artefacts, in addition to global underestimation of the attenuation coefficients due to pile-up. While th main methods of ring artefact correction are purely math ematical, our strategy was to develop a method base d on dead time calibration to be able to remove ring artefacts and at the same time to restore the corre ct quantitative attenuation coefficients. Our original correction method relies on the calibration of the detector dead time map associated to an iterative correction on the sinograms. We performed a fine analysis of dead time dispersion and compared it to our model of pho tonic noise propagation to validate the calibration step. The results of the pile-up correction with a single M dipix3RX ASIC bump bonded to 300 microns Silicon sensor showed quantitative improvements of reconstr uctions of samples acquired using a Siemens X-Ray tube and on the tomographic beam line of the Brazil ian Synchrotron (LNLS).

Correction for pile-up effect based on pixel-by-pixel calibration for tomography with Medipix3RX detector