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The objective of this review is to discuss the effect of trans-10, cis-12 conjugated linoleic acid (CLA) on the milk fat depression syndrome (MFD) in dairy cows. The MFD is characterized by a reduction of up to 50 % of fat concentration in milk, leading to lower yield of dairy products, and consequently, the farmer gets less payment for that milk. There are many theories that discuss MFD; however, the biohydrogenation is the one best supported, which states that a low proportion of neutral detergent fiber or high inclusion of unsaturated fatty acids (FA) into the diet of lactating cows, leads to alterations in ruminal biohydrogenation. This causes an increase of trans FA production, inhibiting those enzymes that are needed to synthesize FA in the mammary gland. The trans-10, cis-12 isomer of CLA is one of the main factors to develop MFD. However, the mechanism is still unclear, but it is known that such isomer suppresses transcription factors that regulate the synthesis of fat in milk.

Síndrome de depresión de grasa láctea provocado por el isómero trans-10, cis-12 del ácido linoleico conjugado en vacas lactantes. Revisión