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Received Mar 4, 2017. Corrected Jun 20, 2017. Accepted Jun 20, 2017. ABSTRACT Introduction: Lung cancer, breast cancer, renal cell cancer, gastrointestinal carcinoma, and melanoma are common sources of cerebral metastasis. Brain metastasis from malignant gynecological tumors are considered rare. According to the literature, fewer than 3% of all brain metastases originate from gynecological lesions. The primary mechanism of metastatic spread from genital tract cancers to the brain is through the hematogenous rout. The endometrial carcinoma metastasis to the brain is a very rare event. The objective of this study is to describe this rare event and conduct a brief review of the literature. Case description: We report on a unique case of a cystic endometrial adenocarcinoma metastasis treated by neurosurgical procedure. The patient underwent “en bloc” tumor resection guided by neuronavigation and there were no complications during surgery. After discharge, she underwent whole brain radiation therapy, currently makes quarterly outpatient follow-up and showed no signals of tumor recurrence. Conclusion: In this article we present a case of cystic brain metastasis from an endometrial adenocarcinoma that was successfully treated by neurosurgery tumoral resection. To our knowledge, this condition has not been reported previously in the literature.

First Case of Isolated Cystic Brain Metastasis from Endometrial Adenocarcinoma Treated by Surgery