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Multidrug resistance is one of the burning issues in medical sciences as it makes bacteria, able to stop antibiotic, working on it. These resistant strains of bacteria make treatment difficult, costly, with addition of prolonged hospital stay and increase rate of mortality. In the recent years 2D carbon nano composite based drugs has proved its potential, against microbial infections due to their high pay load, and site specific drug delivery. Novel nano composite: combination of-protein synthesis inhibitor: gentamicin, conjugated with efficient nano carrier: graphene could result better in antibiotic resistance, on topical infection caused by multi drug resistant E. coli 1614. This study was primarily based on two stages: conjugation of 2D carbon nano material based gentamicin nanocomposite and it’s drug-carrier interaction studies, using FTIR as a tool. There resulted spectra of FTIR showed no significant interaction of the drug with the chosen nano-carrier used in the nanocomposite formulation. In second phase, screening for antibacterial activity, proved gentamicin loaded graphene nanocomposite as an excellent tool against topical infection caused by multidrug resistance strain of E. coli 1614.

pharma innovation

2D carbon nano material based gentamicin nano composite for antibacterial activity against Escherichia coli: A novel strategy towards multidrug resistant bacteria