English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The emergence of antimicrobial resistance is a global concern, particularly in developing countries. The aims of this study were to isolate and identify antimicrobial fractions of C. papaya based on their antimicrobial activity and evaluate the antimicrobial effects of flavonoid to provide natural resources against S. enteretidis, S. typhi, E. coli, S. flexneri and K. pneumonia using the broth microdilution method. The aqueous fraction showed high inhibition potentials against all the tested bacteria with a Minimum Inhibitory Concentration value of 500 μg/mL. Subsequent phytochemical investigation of aqueous fraction by bioactive-guided column chromatography identified by H NMR, C NMR and ESIMS experiments, one new flavonoid named 6"-O-acetyl-3'-O-methyl orientin. The antimicrobial effects of flavonoid against the same pathogens were close to those of the aqueous fraction. This result showed that 6"-O-acetyl-3'-Omethyl orientin is responsible for the antimicrobial activity of Carica papaya leaves and may be considered as antimicrobial lead compound.

Bioguided isolation, structure elucidation and evaluation of new antimicrobial flavonoid from Carica papaya leaves