English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Bioenhancers are the ‘bioavailability enhancers’; they do not show any therapeutic effect, but when used in combination enhances the activ ity of drug molecule. In a cited research paper, the effect of various species of piper used as bioenhancer singly and in combina tion in an equal ratio. The methods used for preparation of microspheres are Complex Coacervation and Modified Emulsion Method. The prepared microspheres were evaluated for various parameters like in-vitro release, drug entrapment efficiency, percent bioadhesion, permeability study using intestinal sac method. The in-vitro drug release of drugs from formulations where Piper nigrum was used as bioenhancers was found to be about 66-70% in 12 hrs. when used singly. When bioenhancers used in combination the in-vitro drug release of drugs was increased up to 8590% for combination of Piper album and Piper longum in an equal proportion, the same was about 35-40% in case of formulations where no bioenhancers was used. The microspheres found to be less than 130 micron in size. The DEE was found to be in the range of 27-67%. The bioadhesion of the microsphere were found to be 20-76% (increased in formulations where bioenhancers incorporated). The invitro release study by USP paddle apparatus, the important results from in-vitro release study relates to the very significant enhancement in drug release, due to presence of bioenhancers.

journal of drug delivery and therapeutics

Comparative Study of Herbal Extract of Piper Nigrum, Piper Album and Piper Longum on Various Characteristics of Pyrazinamide and Ethambutol Microspheres