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Objective : To study the effects of TiO 2 nanoparticles in mice and explore the biological safety of TiO 2 nanoparticles. Methods : The biological safety of TiO 2 nanoparticles based on the oxidative stress pathway is investigated. One hundred mice were randomly divided into 10 groups. A low medium and high concentration experimental group and negative and positive control groups were investigated for both the intravenous injection and tracheal injection exposure experiments. Mice were observed for any symptoms, and the serum and lung homogenate for activity of SOD and content of MDA in serum and lung tissue were prepared. The scores of the allergic reaction determined the degree of anti-oxidation and the comprehensive experimental data determined the degree of injury in the mice. Results : An increase of TiO 2 concentration in the nanomaterials led to a decrease of the content of MDA in serum and lung tissue of mice and the activity of SOD increased, indicating that mice showed oxidative stress in vivo. Conclusion : The strong direct exposure to a high concentration of TiO 2 nanoparticles was harmful to the organism. 1 Key words : Foundation medicine; TiO 2 ; Nanoparticles; Oxidative stress; Biosafety nanomaterials

Study on the biological safety of TiO2 nanoparticles based on the oxidative stress pathway