English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Acyclovir, an anti-viral drug widely used in the treatment of herpes simplex virus infections, characterized by low aqueous solubility. The present study focuses on the formulation and evaluation of Acyclovir fast dissolving tablets which offer a solution for those patients having difficulty in swallowing. In the formulation of fast dissolving tablets of acyclovir, superdisintegrants like starch phthalate (a novel superdisintegrant), croscarmellose sodium and crospovidone are employed. The synthesized starch phthalate was characterized by FTIR, X-ray etc. The Acyclovir - Starch phthalate compatibility studies like DSC, FTIR and TLC were done. From the results, it was observed that no chemical interaction between the drug and starch phthalate confirmed. 23 factorial design was used in formulation of tablets to obtain the ideal concentration of starch phthalate that is to be used in the formulation of fast dissolving tablets with less experimentation and in short period of time. Acyclovir fast dissolving tablets were subjected to various physical tests and in-vitro dissolution studies. The studies revealed that concentration of 10% w/w of starch phthalate can be used as superdisintegrant in the formulation of fast dissolving of fast dissolving tablets. Keywords: Acyclovir, Starch phthalate, Fast Dissolving Tablets, 23factorial design, Superdisintegrant.

ISOLATION, CHARACTERIZATION AND INVESTIGATION OF STARCH PHTHALATE AS NOVEL SUPERDISINTEGRANT IN DEVELOPING OF ACYCLOVIR FAST DISSOLVING TABLETS