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Recent development in fast disintegrating technology mainly works to improve the quality of these delicate dosage forms without affecting their integrity. Current investigations deal with the formulation of fast dissolving tablet of Ondansetron HCl with the effect of different co-processed excipients by using ball mill that disintegrates in oral cavity on contact with saliva & thereby improve therapeutic efficacy because the mannitol was stick to dies and punch therefore ball mill is used to prepare co ground mixtures of crospovidone and mannitol to improve the compatibility and stability of product. The Fast disintegrating tablets of Ondansetron HCl were prepared by direct compression method using different synthetic superdisintegrant such as Crospovidone, and natural superdisintegranst such as Karaya gum and Fenugreek gum in different concentration. The FTIR, DSC analysis revealed that the Betacyclodextrin and superdisintegrants used were compatible with Ondansetron HCl. A complex of Betacyclodextrin and Ondansetron HCl was successfully formed in 1:2 ratios. Disintegration time decrease with increase in the concentration o superdisintegrant. Among all formulation, containing Karaya Gum as superdisintegrants is fulfilling all the parameters satisfactorily. In vitro release studies that almost 98.88% of the drug was released from all the formulation were within 15 minutes. Best Formulation F6 showed faster drug release within 7 minutes in comparison to other formulation. ThE result shows that Co-processing of excipients is the most suitable approach for formulation of Fast dissolving tablet. Keywords: Coprocess, Fast disintegrating tablets, Ball mill, Disintegration time, Mannitol etc. Â

FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLET OF ONDANSETRON HYDROCHLORIDE BY COPROCESS EXCIPIENTS